1,2-Dithiole-3-Ones as Potent Inhibitors of the Bacterial 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)

The enzyme FabH catalyzes the initial step of fatty acid biosynthesis via a type II dissociated fatty acid synthase. The pivotal role of this essential enzyme, combined with its unique structural features and ubiquitous occurrence in bacteria, has made it an attractive new target for the development...

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Détails bibliographiques
Auteurs principaux: He, Xin, Reeve, Anne McElwee, Desai, Umesh R., Kellogg, Glen E., Reynolds, Kevin A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2004
Sujets:
Chemistry; Biosynthesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC478545/
https://ncbi.nlm.nih.gov/pubmed/15273125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.3093-3102.2004
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