1,2-Dithiole-3-Ones as Potent Inhibitors of the Bacterial 3-Ketoacyl Acyl Carrier Protein Synthase III (FabH)

The enzyme FabH catalyzes the initial step of fatty acid biosynthesis via a type II dissociated fatty acid synthase. The pivotal role of this essential enzyme, combined with its unique structural features and ubiquitous occurrence in bacteria, has made it an attractive new target for the development...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	He, Xin, Reeve, Anne McElwee, Desai, Umesh R., Kellogg, Glen E., Reynolds, Kevin A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2004
Soggetti:	Chemistry; Biosynthesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC478545/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15273125/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.8.3093-3102.2004
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