Cellular Pharmacokinetics and Pharmacodynamics of the Glycopeptide Antibiotic Oritavancin (LY333328) in a Model of J774 Mouse Macrophages

The intracellular pharmacokinetics and pharmacodynamics of oritavancin (LY333328) were studied in cultured cells. Oritavancin was avidly accumulated by J774 and THP-1 macrophages and rat fibroblasts and to a lesser extent by LLC-PK1 and Caco-2 cells. In J774 macrophages, the level of accumulation re...

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Autors principals: Van Bambeke, Françoise, Carryn, Stéphane, Seral, Cristina, Chanteux, Hugues, Tyteca, Donatienne, Mingeot-Leclercq, Marie-Paule, Tulkens, Paul M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC478544/
https://ncbi.nlm.nih.gov/pubmed/15273091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.2853-2860.2004
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