The three-dimensional structure of Clostridium absonum 7α-hydroxysteroid dehydrogenase: new insights into the conserved arginines for NADP(H) recognition

7α-hydroxysteroid dehydrogenase (7α-HSDH) can catalyse the oxidation of C7 α-OH of the steroid nucleus in the bile acid metabolism. In the paper we determined the crystal structure of 7α-HSDH from Clostridium absonum (CA 7α-HSDH) complexed with taurochenodeoxycholic acid (TCDCA) and NADP(+) by X-ray...

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Foilsithe in:Sci Rep
Main Authors: Lou, Deshuai, Wang, Bochu, Tan, Jun, Zhu, Liancai, Cen, Xiaoxi, Ji, Qingzhi, Wang, Yue
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785404/
https://ncbi.nlm.nih.gov/pubmed/26961171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22885
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