NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease

Oxidative stress and aberrant accumulation of misfolded proteins in the cytosol are key pathological features associated with Parkinson’s disease (PD). NADPH oxidase (Nox2) is upregulated in the pathogenesis of PD; however, the underlying mechanism(s) of Nox2-mediated oxidative stress in PD pathogen...

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Vydáno v:Sci Rep
Hlavní autoři: Pal, Rituraj, Bajaj, Lakshya, Sharma, Jaiprakash, Palmieri, Michela, Di Ronza, Alberto, Lotfi, Parisa, Chaudhury, Arindam, Neilson, Joel, Sardiello, Marco, Rodney, George G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785399/
https://ncbi.nlm.nih.gov/pubmed/26960433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22866
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