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Copy Number Variations in the Survival Motor Neuron Genes: Implications for Spinal Muscular Atrophy and Other Neurodegenerative Diseases

Proximal spinal muscular atrophy (SMA), a leading genetic cause of infant death worldwide, is an early-onset, autosomal recessive neurodegenerative disease characterized by the loss of spinal α-motor neurons. This loss of α-motor neurons is associated with muscle weakness and atrophy. SMA can be cla...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Autor principal: Butchbach, Matthew E. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785180/
https://ncbi.nlm.nih.gov/pubmed/27014701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00007
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