Inhibitors of Leishmania mexicana CRK3 Cyclin-Dependent Kinase: Chemical Library Screen and Antileishmanial Activity

The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of CRK3 impairs the parasite's viability within macrophages, thus further validating CRK3 as a pote...

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מידע ביבליוגרפי
Main Authors: Grant, Karen M., Dunion, Morag H., Yardley, Vanessa, Skaltsounis, Alexios-Leandros, Marko, Doris, Eisenbrand, Gerhard, Croft, Simon L., Meijer, Laurent, Mottram, Jeremy C.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 2004
נושאים:
Mechanisms of Action: Physiological Effects
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC478496/
https://ncbi.nlm.nih.gov/pubmed/15273118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.3033-3042.2004
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