Inhibitors of Leishmania mexicana CRK3 Cyclin-Dependent Kinase: Chemical Library Screen and Antileishmanial Activity

The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of CRK3 impairs the parasite's viability within macrophages, thus further validating CRK3 as a pote...

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Bibliographic Details
Main Authors: Grant, Karen M., Dunion, Morag H., Yardley, Vanessa, Skaltsounis, Alexios-Leandros, Marko, Doris, Eisenbrand, Gerhard, Croft, Simon L., Meijer, Laurent, Mottram, Jeremy C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC478496/
https://ncbi.nlm.nih.gov/pubmed/15273118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.3033-3042.2004
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