Inhibitors of Leishmania mexicana CRK3 Cyclin-Dependent Kinase: Chemical Library Screen and Antileishmanial Activity

The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of CRK3 impairs the parasite's viability within macrophages, thus further validating CRK3 as a pote...

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Auteurs principaux: Grant, Karen M., Dunion, Morag H., Yardley, Vanessa, Skaltsounis, Alexios-Leandros, Marko, Doris, Eisenbrand, Gerhard, Croft, Simon L., Meijer, Laurent, Mottram, Jeremy C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2004
Sujets:
Mechanisms of Action: Physiological Effects
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC478496/
https://ncbi.nlm.nih.gov/pubmed/15273118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.3033-3042.2004
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