Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids

Expansion of the genetic code with nonstandard amino acids (nsAAs) has enabled biosynthesis of proteins with diverse new chemistries. However, this technology has been largely restricted to proteins containing a single or few nsAA instances. Here we describe an in vivo evolution approach in a genomi...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Amiram, Miriam, Haimovich, Adrian D, Fan, Chenguang, Wang, Yane-Shih, Aerni, Hans-Rudolf, Ntai, Ioanna, Moonan, Daniel W, Ma, Natalie J, Rovner, Alexis J, Hong, Seok Hoon, Kelleher, Neil L, Goodman, Andrew L, Jewett, Michael C, Söll, Dieter, Rinehart, Jesse, Isaacs, Farren J
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784704/
https://ncbi.nlm.nih.gov/pubmed/26571098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3372
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