Oral Immunization with Recombinant Vaccinia Virus Prime and Intramuscular Protein Boost Provides Protection against Intrarectal Simian-Human Immunodeficiency Virus Challenge in Macaques

Human immunodeficiency virus type 1 (HIV-1) acquisition occurs predominantly through mucosal transmission. We hypothesized that greater mucosal immune responses and protective efficacy against mucosal HIV-1 infection may be achieved by prime-boost immunization at mucosal sites. We used a macaque mod...

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Опубликовано в: :Clin Vaccine Immunol
Главные авторы: Thippeshappa, Rajesh, Tian, Baoping, Cleveland, Brad, Guo, Wenjin, Polacino, Patricia, Hu, Shiu-Lok
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2016
Предметы:
Vaccines
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783425/
https://ncbi.nlm.nih.gov/pubmed/26718849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00597-15
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