Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen

DNA and modified vaccinia virus Ankara (MVA) are vaccine vehicles suitable and safe for use in humans. Here, by using a multicytotoxic T-lymphocyte (CTL) epitope gene and a DNA prime-MVA boost vaccination regimen, high levels of CTLs specific for a single simian immunodeficiency virus (SIV) gag-deri...

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Bibliographic Details
Main Authors: Hanke, Tomas, Samuel, Rachel V., Blanchard, Tom J., Neumann, Veronica C., Allen, Todd M., Boyson, Jon E., Sharpe, Sally A., Cook, Nicola, Smith, Geoffrey L., Watkins, David I., Cranage, Martin P., McMichael, Andrew J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC104279/
https://ncbi.nlm.nih.gov/pubmed/10438842
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