Increased surface expression of HIV-1 envelope is associated with improved antibody response in vaccinia prime/protein boost immunization

HIV-1 envelope (Env)-based vaccines have so far largely failed to induce antibodies that prevent HIV-1 infection. One factor proposed to limit the immunogenicity of cell-associated Env is its low level of expression on the cell surface, restricting accessibility to antibodies. Using a vaccinia prime...

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Publicado no:Virology
Main Authors: Hogan, Michael J., Conde-Motter, Angela, Jordan, Andrea P.O., Yang, Lifei, Cleveland, Brad, Guo, Wenjin, Romano, Josephine, Ni, Houping, Pardi, Norbert, LaBranche, Celia C., Montefiori, David C., Hu, Shiu-Lok, Hoxie, James A., Weissman, Drew
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5770335/
https://ncbi.nlm.nih.gov/pubmed/29175625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.10.013
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