Induction of Heterologous Tier 2 HIV-1-Neutralizing and Cross-Reactive V1/V2-Specific Antibodies in Rabbits by Prime-Boost Immunization

Poxvirus prime-protein boost used in the RV144 trial remains the only immunization strategy shown to elicit a modest level of protection against HIV-1 acquisition in humans. Although neutralizing antibodies (NAb) were generated, they were against sensitive viruses, not the more resistant “tier 2” is...

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Vydáno v:J Virol
Hlavní autoři: Townsley, Samantha, Mohamed, Zeinab, Guo, Wenjin, McKenna, Jennifer, Cleveland, Brad, LaBranche, Celia, Beaumont, David, Shen, Xiaoying, Yates, Nicole L., Pinter, Abraham, Tomaras, Georgia D., Ferrari, Guido, Montefiori, David C., Hu, Shiu-Lok
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021413/
https://ncbi.nlm.nih.gov/pubmed/27440894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00853-16
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