Combination of nanoparticle-delivered siRNA for Astrocyte elevated gene-1 (AEG-1) and all-trans retinoic acid (ATRA): an effective therapeutic strategy for hepatocellular carcinoma (HCC)

Hepatocellular carcinoma (HCC) is a fatal cancer with no effective therapy. Astrocyte elevated gene-1 (AEG-1) plays a pivotal role in hepatocarcinogenesis and inhibits retinoic acid-induced gene expression and cell death. Combination of a lentivirus expressing AEG-1 shRNA and all-trans retinoic acid...

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Détails bibliographiques
Publié dans:Bioconjug Chem
Auteurs principaux: Rajasekaran, Devaraja, Srivastava, Jyoti, Ebeid, Kareem, Gredler, Rachel, Akiel, Maaged, Jariwala, Nidhi, Robertson, Chadia L., Shen, Xue-Ning, Siddiq, Ayesha, Fisher, Paul B., Salem, Aliasger K., Sarkar, Devanand
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783168/
https://ncbi.nlm.nih.gov/pubmed/26079152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.5b00254
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