Genetic deletion of AEG-1 prevents hepatocarcinogenesis

Activation of the oncogene AEG-1 (MTDH, LYRIC) has been implicated recently in the development of hepatocellular carcinoma (HCC). In mice, HCC can be initiated by exposure to the carcinogen DEN, which has been shown to rely upon activation of NF-κB in liver macrophages. Since AEG-1 is an essential c...

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Hauptverfasser: Robertson, Chadia L., Srivastava, Jyoti, Siddiq, Ayesha, Gredler, Rachel, Emdad, Luni, Rajasekaran, Devaraja, Akiel, Maaged, Shen, Xue-Ning, Guo, Chunqing, Giashuddin, Shah, Wang, Xiang-Yang, Ghosh, Shobha, Subler, Mark A, Windle, Jolene J., Fisher, Paul B., Sarkar, Devanand
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216744/
https://ncbi.nlm.nih.gov/pubmed/25193383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1357
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