Safety and biodistribution of a double-deleted oncolytic vaccinia virus encoding CD40 ligand in laboratory Beagles

We evaluated adverse events, biodistribution and shedding of oncolytic vaccinia virus encoding CD40 ligand in two Beagles, in preparation for a phase 1 trial in canine cancer patients. Dog 1 received one dose of vaccinia virus and was euthanized 24 hours afterwards, while dog 2 received virus four t...

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Bibliografiske detaljer
Udgivet i:Mol Ther Oncolytics
Main Authors: Autio, Karoliina, Knuuttila, Anna, Kipar, Anja, Pesonen, Sari, Guse, Kilian, Parviainen, Suvi, Rajamäki, Minna, Laitinen-Vapaavuori, Outi, Vähä-Koskela, Markus, Kanerva, Anna, Hemminki, Akseli
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782937/
https://ncbi.nlm.nih.gov/pubmed/27119092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2014.2
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