Non-enzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress

WRN, the protein defective in Werner Syndrome (WS), is a multifunctional nuclease involved in DNA damage repair, replication and genome stability maintenance. It was assumed that the nuclease activities of WRN were critical for these functions. Here, we report a non-enzymatic role for WRN in preserv...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Su, Fengtao, Mukherjee, Shibani, Yang, Yanyong, Mori, Eiichiro, Bhattacharya, Souparno, Kobayashi, Junya, Yannone, Steven M., Chen, David J., Asaithamby, Aroumougame
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782925/
https://ncbi.nlm.nih.gov/pubmed/25456133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.025
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