Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway

Faithful and complete genome replication in human cells is essential for preventing the accumulation of cancer-promoting mutations. WRN, the protein defective in Werner syndrome, plays critical roles in preventing replication stress, chromosome instability, and tumorigenesis. Herein, we report that...

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Publicado en:Oncotarget
Autores principales: Su, Fengtao, Bhattacharya, Souparno, Abdisalaam, Salim, Mukherjee, Shibani, Yajima, Hirohiko, Yang, Yanyong, Mishra, Ritu, Srinivasan, Kalayarasan, Ghose, Subroto, Chen, David J., Yannone, Steven M., Asaithamby, Aroumougame
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807982/
https://ncbi.nlm.nih.gov/pubmed/26695548
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