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A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

Most cancers in humans are large, measuring centimetres in diameter, and composed of many billions of cells(1). An equivalent mass of normal cells would be highly heterogeneous as a result of the mutations that occur during each cell division. What is remarkable about cancers is that virtually every...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nature
Prif Awduron: Waclaw, Bartlomiej, Bozic, Ivana, Pittman, Meredith E., Hruban, Ralph H., Vogelstein, Bert, Nowak, Martin A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782800/
https://ncbi.nlm.nih.gov/pubmed/26308893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14971
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