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Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine

Depression is a common co-morbid condition most often observed in subjects with mild cognitive impairment (MCI) and during the early stages of Alzheimer’s disease (AD). Dysfunction of the central noradrenergic nervous system is an important component in depression. In AD, locus coeruleus (LC) noradr...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Szot, Patricia, Franklin, Allyn, Miguelez, Cristina, Wang, Yangqing, Vidaurrazaga, Igor, Ugedo, Luisa, Sikkema, Carl, Wilkinson, Charles W., Raskind, Murray A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782767/
https://ncbi.nlm.nih.gov/pubmed/26362360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.09.003
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