Sequential Loss of LC Noradrenergic and Dopaminergic Neurons Results in a Correlation of Dopaminergic Neuronal Number to Striatal Dopamine Concentration

Noradrenergic neurons in the locus coeruleus (LC) are significantly reduced in Parkinson’s disease (PD) and the LC exhibits neuropathological changes early in the disease process. It has been suggested that a loss of LC neurons can enhance the susceptibility of dopaminergic neurons to damage. To det...

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Autori principali: Szot, Patricia, Franklin, Allyn, Sikkema, Carl, Wilkinson, Charles W., Raskind, Murray A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2012
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3487487/
https://ncbi.nlm.nih.gov/pubmed/23129999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00184
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