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Mus81 and converging forks limit the mutagenicity of replication fork breakage
Most spontaneous DNA double-strand breaks (DSBs) result from replication-fork breakage. Break-induced replication (BIR), a genome rearrangement-prone repair mechanism that requires the Pol32/POLD3 subunit of eukaryotic DNA Polδ, was proposed to repair broken forks, but how genome destabilization is...
Gorde:
| Argitaratua izan da: | Science |
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| Egile Nagusiak: | , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4782627/ https://ncbi.nlm.nih.gov/pubmed/26273056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa8391 |
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