Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ(2)-mediated cell death

Despite considerable efforts to improve treatment modalities for osteosarcoma (OS), patient survival remains poor mainly due to pro-survival pathways in OS cells. Among others, prostaglandins (PGs) are the potent regulators of bone homoeostasis and OS pathophysiology. Therefore, the present study ai...

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Vydáno v:Biochem Pharmacol
Hlavní autoři: Koyani, Chintan N., Kitz, Kerstin, Rossmann, Christine, Bernhart, Eva, Huber, Evelyn, Trummer, Christopher, Windischhofer, Werner, Sattler, Wolfgang, Malle, Ernst
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782222/
https://ncbi.nlm.nih.gov/pubmed/26801686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.01.011
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