Elimination of HIV-1-infected cells by broadly neutralizing antibodies

The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for suppressing viraemia, through mechanisms which remain poorly understood. Here, we identify bNAbs that exert antibody-dependent cellular cytotoxicity (ADCC) in cell culture and kill HIV-1-infected lymphocytes...

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Pubblicato in:Nat Commun
Autori principali: Bruel, Timothée, Guivel-Benhassine, Florence, Amraoui, Sonia, Malbec, Marine, Richard, Léa, Bourdic, Katia, Donahue, Daniel Aaron, Lorin, Valérie, Casartelli, Nicoletta, Noël, Nicolas, Lambotte, Olivier, Mouquet, Hugo, Schwartz, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782064/
https://ncbi.nlm.nih.gov/pubmed/26936020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10844
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