Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation

Poly(C)-binding protein 4 (PCBP4), also called MCG10 and a target of p53, plays a role in the cell cycle and is implicated in lung tumor suppression. Here, we found that PCBP4-deficient mice are prone to lung adenocarcinoma, lymphoma, and kidney tumor and that PCBP4-deficient mouse embryo fibroblast...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes Dev
Prif Awduron: Yan, Wensheng, Scoumanne, Ariane, Jung, Yong-Sam, Xu, Enshun, Zhang, Jin, Zhang, Yanhong, Ren, Cong, Sun, Pei, Chen, Xinbin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2016
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782047/
https://ncbi.nlm.nih.gov/pubmed/26915821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.271890.115
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