Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice.
One hallmark of Alzheimer disease is the formation in the brain of amyloid plaques containing a small peptide derived from the beta-amyloid precursor protein (APP). The APP gene exhibits a complex pattern of expression in peripheral tissues and in the brain. The entire human APP gene was introduced...
Guardat en:
| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1993
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47820/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8248147/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.22.10578 |
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