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Expression of the human beta-amyloid precursor protein gene from a yeast artificial chromosome in transgenic mice.

One hallmark of Alzheimer disease is the formation in the brain of amyloid plaques containing a small peptide derived from the beta-amyloid precursor protein (APP). The APP gene exhibits a complex pattern of expression in peripheral tissues and in the brain. The entire human APP gene was introduced...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Pearson, B E, Choi, T K
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1993
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47820/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8248147/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.22.10578
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