A New Nanobody-Based Biosensor to Study Endogenous PARP1 In Vitro and in Live Human Cells

Poly(ADP-ribose) polymerase 1 (PARP1) is a key player in DNA repair, genomic stability and cell survival and it emerges as a highly relevant target for cancer therapies. To deepen our understanding of PARP biology and mechanisms of action of PARP1-targeting anti-cancer compounds, we generated a nove...

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Publicado en:PLoS One
Main Authors: Buchfellner, Andrea, Yurlova, Larisa, Nüske, Stefan, Scholz, Armin M., Bogner, Jacqueline, Ruf, Benjamin, Zolghadr, Kourosh, Drexler, Sophie E., Drexler, Guido A., Girst, Stefanie, Greubel, Christoph, Reindl, Judith, Siebenwirth, Christian, Romer, Tina, Friedl, Anna A., Rothbauer, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780744/
https://ncbi.nlm.nih.gov/pubmed/26950694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151041
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