Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1

T cell infiltration into colorectal tumors has been shown to correlate with improved patient outcomes. However, more detailed information on the makeup and relationships between the infiltrating T cell subsets is lacking. We therefore correlated the extent of immune infiltration into colorectal tumo...

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Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Dunne, Margaret R., Ryan, Ciara, Nolan, Bláthnaid, Tosetto, Miriam, Geraghty, Robert, Winter, Des C., O’Connell, P. Ronan, Hyland, John M., Doherty, Glen A., Sheahan, Kieran, Ryan, Elizabeth J., Fletcher, Jean M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2016
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780371/
https://ncbi.nlm.nih.gov/pubmed/27014625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2016.00050
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