Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1

T cell infiltration into colorectal tumors has been shown to correlate with improved patient outcomes. However, more detailed information on the makeup and relationships between the infiltrating T cell subsets is lacking. We therefore correlated the extent of immune infiltration into colorectal tumo...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Dunne, Margaret R., Ryan, Ciara, Nolan, Bláthnaid, Tosetto, Miriam, Geraghty, Robert, Winter, Des C., O’Connell, P. Ronan, Hyland, John M., Doherty, Glen A., Sheahan, Kieran, Ryan, Elizabeth J., Fletcher, Jean M.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780371/
https://ncbi.nlm.nih.gov/pubmed/27014625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2016.00050
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