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A long journey coming to fruition: In sight of the pre-selection T-cell repertoire

In addition to MHC restriction and its structural correlate, the recognition of an MHC-peptide complex by the T-cell antigen receptor (TCR), T-cell reactivity is constrained by positive and negative selection in the thymus. While mouse genetic studies have provided compelling evidence for both proce...

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Detalles Bibliográficos
Publicado en:Eur J Immunol
Main Authors: Ciucci, Thomas, Bosselut, Rémy
Formato: Artigo
Idioma:Inglês
Publicado: 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779685/
https://ncbi.nlm.nih.gov/pubmed/26846172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201646292
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