BRAF(V600E) induces ABCB1/P-glycoprotein expression and drug resistance in B-cells via AP-1 activation

A subset of patients with chronic lymphocytic leukemia (CLL) and nearly all patients with classic hairy cell leukemia (HCL) harbor somatic BRAF activating mutations. However, the pathological role of activated BRAF in B-cell leukemia development and progression remains unclear. In addition, although...

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Pubblicato in:Leuk Res
Autori principali: Tsai, Yo-Ting, Lozanski, Gerard, Lehman, Amy, Sass, Ellen J., Hertlein, Erin, Salunke, Santosh B., Chen, Ching-Shih, Grever, Michael R., Byrd, John C., Lucas, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779435/
https://ncbi.nlm.nih.gov/pubmed/26350141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2015.08.017
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