BRAF(V600E) induces ABCB1/P-glycoprotein expression and drug resistance in B-cells via AP-1 activation

A subset of patients with chronic lymphocytic leukemia (CLL) and nearly all patients with classic hairy cell leukemia (HCL) harbor somatic BRAF activating mutations. However, the pathological role of activated BRAF in B-cell leukemia development and progression remains unclear. In addition, although...

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Publicado no:Leuk Res
Principais autores: Tsai, Yo-Ting, Lozanski, Gerard, Lehman, Amy, Sass, Ellen J., Hertlein, Erin, Salunke, Santosh B., Chen, Ching-Shih, Grever, Michael R., Byrd, John C., Lucas, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779435/
https://ncbi.nlm.nih.gov/pubmed/26350141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2015.08.017
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