BRAF(V600E) induces ABCB1/P-glycoprotein expression and drug resistance in B-cells via AP-1 activation

A subset of patients with chronic lymphocytic leukemia (CLL) and nearly all patients with classic hairy cell leukemia (HCL) harbor somatic BRAF activating mutations. However, the pathological role of activated BRAF in B-cell leukemia development and progression remains unclear. In addition, although...

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Bibliografske podrobnosti
izdano v:Leuk Res
Main Authors: Tsai, Yo-Ting, Lozanski, Gerard, Lehman, Amy, Sass, Ellen J., Hertlein, Erin, Salunke, Santosh B., Chen, Ching-Shih, Grever, Michael R., Byrd, John C., Lucas, David M.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779435/
https://ncbi.nlm.nih.gov/pubmed/26350141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2015.08.017
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