Resistance to the Translation Initiation Inhibitor Silvestrol is Mediated by ABCB1/P-Glycoprotein Overexpression in Acute Lymphoblastic Leukemia Cells

Protein synthesis is a powerful therapeutic target in leukemias and other cancers, but few pharmacologically viable agents are available that affect this process directly. The plant-derived agent silvestrol specifically inhibits translation initiation by interfering with eIF4A/mRNA assembly with eIF...

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Bibliografiske detaljer
Main Authors: Gupta, Sneha V., Sass, Ellen J., Davis, Melanie E., Edwards, Ryan B., Lozanski, Gerard, Heerema, Nyla A., Lehman, Amy, Zhang, Xiaoli, Jarjoura, David, Byrd, John C., Pan, Li, Chan, Kenneth K., Kinghorn, A. Douglas, Phelps, Mitch A., Grever, Michael R., Lucas, David M.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2011
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160166/
https://ncbi.nlm.nih.gov/pubmed/21538216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9276-7
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