Whole-Exome Sequencing Reveals Mutations in Genes Linked to Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome in Fatal Cases of H1N1 Influenza

Background. Severe H1N1 influenza can be lethal in otherwise healthy individuals and can have features of reactive hemophagocytic lymphohistiocytosis (HLH). HLH is associated with mutations in lymphocyte cytolytic pathway genes, which have not been previously explored in H1N1 influenza. Methods. Six...

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Dades bibliogràfiques
Publicat a:J Infect Dis
Autors principals: Schulert, Grant S., Zhang, Mingce, Fall, Ndate, Husami, Ammar, Kissell, Diane, Hanosh, Andrew, Zhang, Kejian, Davis, Kristina, Jentzen, Jeffrey M., Napolitano, Lena, Siddiqui, Javed, Smith, Lauren B., Harms, Paul W., Grom, Alexei A., Cron, Randy Q.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779301/
https://ncbi.nlm.nih.gov/pubmed/26597256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv550
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