A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity

Drug-induced nephrotoxicity still hampers drug development, because current translation from in vitro or animal studies to human lacks high predictivity. Often, renal adverse effects are recognized only during clinical stages of drug development. The current study aimed to establish a robust and a m...

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Dettagli Bibliografici
Pubblicato in:AAPS J
Autori principali: Nieskens, Tom T. G., Peters, Janny G. P., Schreurs, Marieke J., Smits, Niels, Woestenenk, Rob, Jansen, Katja, van der Made, Thom K., Röring, Melanie, Hilgendorf, Constanze, Wilmer, Martijn J, Masereeuw, Rosalinde
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779111/
https://ncbi.nlm.nih.gov/pubmed/26821801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-016-9871-8
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