A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity

Drug-induced nephrotoxicity still hampers drug development, because current translation from in vitro or animal studies to human lacks high predictivity. Often, renal adverse effects are recognized only during clinical stages of drug development. The current study aimed to establish a robust and a m...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Nieskens, Tom T. G., Peters, Janny G. P., Schreurs, Marieke J., Smits, Niels, Woestenenk, Rob, Jansen, Katja, van der Made, Thom K., Röring, Melanie, Hilgendorf, Constanze, Wilmer, Martijn J, Masereeuw, Rosalinde
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779111/
https://ncbi.nlm.nih.gov/pubmed/26821801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-016-9871-8
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