Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence

The two-component system PhoP-PhoQ is highly conserved in bacteria and regulates virulence in response to various signals for bacteria within the mammalian host. Here, we demonstrate that PhoP could be acetylated by Pat and deacetylated by deacetylase CobB enzymatically in vitro and in vivo in Salmo...

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Bibliographic Details
Published in:PLoS Pathog
Main Authors: Ren, Jie, Sang, Yu, Tan, Yongcong, Tao, Jing, Ni, Jinjing, Liu, Shuting, Fan, Xia, Zhao, Wei, Lu, Jie, Wu, Wenjuan, Yao, Yu-Feng
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778762/
https://ncbi.nlm.nih.gov/pubmed/26943369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005458
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