Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence

The two-component system PhoP-PhoQ is highly conserved in bacteria and regulates virulence in response to various signals for bacteria within the mammalian host. Here, we demonstrate that PhoP could be acetylated by Pat and deacetylated by deacetylase CobB enzymatically in vitro and in vivo in Salmo...

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Publicat a:PLoS Pathog
Autors principals: Ren, Jie, Sang, Yu, Tan, Yongcong, Tao, Jing, Ni, Jinjing, Liu, Shuting, Fan, Xia, Zhao, Wei, Lu, Jie, Wu, Wenjuan, Yao, Yu-Feng
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778762/
https://ncbi.nlm.nih.gov/pubmed/26943369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005458
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