Design, Synthesis and Evaluation of Triazole-Pyrimidine Analogues as SecA Inhibitors

SecA, a key component of bacterial Sec-dependent secretion pathway, is an attractive target for novel antimicrobial development. Through a combination of virtual screening and experimental exploration of surrounding chemical space, we identified a hit bistriazole SecA inhibitor, SCA-21, and studied...

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Publicado no:ChemMedChem
Main Authors: Cui, Jianmei, Jin, Jinshan, Chaudhary, Arpana Sagwal, Hsieh, Ying-hsin, Zhang, Hao, Dai, Chaofeng, Damera, Krishna, Chen, Weixuan, Tai, Phang C., Wang, Binghe
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778717/
https://ncbi.nlm.nih.gov/pubmed/26607404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201500447
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