Pevonedistat, a NEDD8-activating enzyme inhibitor, is active in mantle cell lymphoma and enhances rituximab activity in vivo

Mantle cell lymphoma (MCL) is characterized by an aggressive clinical course and inevitable development of refractory disease, stressing the need to develop alternative therapeutic strategies. To this end, we evaluated pevonedistat (MLN4924), a novel potent and selective NEDD8-activating enzyme inhi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Czuczman, Natalie M., Barth, Matthew J., Gu, Juan, Neppalli, Vishala, Mavis, Cory, Frys, Sarah E., Hu, Qiang, Liu, Song, Klener, Pavel, Vockova, Petra, Czuczman, Myron S., Hernandez-Ilizaliturri, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778163/
https://ncbi.nlm.nih.gov/pubmed/26675347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-640920
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