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The novel proteasome inhibitor carfilzomib (CFZ) induces cell cycle arrest, apoptosis and potentiates the anti-tumour activity of chemotherapy in rituximab-resistant lymphoma

Targeting the proteasome system with bortezomib (BTZ) results in anti-tumour activity and potentiates the effects of chemotherapy/biological agents in multiple myeloma and B-cell lymphoma. Carfilzomib (CFZ) is a more selective proteasome inhibitor that is structurally distinct from BTZ. In an attemp...

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Détails bibliographiques
Auteurs principaux: Gu, Juan J., Hernandez-Ilizaliturri, Francisco J., Kaufman, Gregory P., Czuczman, Natalie M., Mavis, Cory, Skitzki, Joseph J., Czuczman, Myron S.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760501/
https://ncbi.nlm.nih.gov/pubmed/23826755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.12452
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