Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a stable and directly interacting bona fide AMPAR auxiliary subunit. Shisa6 is enriched at hippocampal postsynaptic m...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Klaassen, Remco V., Stroeder, Jasper, Coussen, Françoise, Hafner, Anne-Sophie, Petersen, Jennifer D., Renancio, Cedric, Schmitz, Leanne J. M., Normand, Elisabeth, Lodder, Johannes C., Rotaru, Diana C., Rao-Ruiz, Priyanka, Spijker, Sabine, Mansvelder, Huibert D., Choquet, Daniel, Smit, August B.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778035/
https://ncbi.nlm.nih.gov/pubmed/26931375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10682
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