Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a stable and directly interacting bona fide AMPAR auxiliary subunit. Shisa6 is enriched at hippocampal postsynaptic m...

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Publicat a:Nat Commun
Autors principals: Klaassen, Remco V., Stroeder, Jasper, Coussen, Françoise, Hafner, Anne-Sophie, Petersen, Jennifer D., Renancio, Cedric, Schmitz, Leanne J. M., Normand, Elisabeth, Lodder, Johannes C., Rotaru, Diana C., Rao-Ruiz, Priyanka, Spijker, Sabine, Mansvelder, Huibert D., Choquet, Daniel, Smit, August B.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778035/
https://ncbi.nlm.nih.gov/pubmed/26931375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10682
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