Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity

Trafficking and biophysical properties of AMPA receptors (AMPARs) in the brain depend on interactions with associated proteins. We identify Shisa6, a single transmembrane protein, as a stable and directly interacting bona fide AMPAR auxiliary subunit. Shisa6 is enriched at hippocampal postsynaptic m...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Klaassen, Remco V., Stroeder, Jasper, Coussen, Françoise, Hafner, Anne-Sophie, Petersen, Jennifer D., Renancio, Cedric, Schmitz, Leanne J. M., Normand, Elisabeth, Lodder, Johannes C., Rotaru, Diana C., Rao-Ruiz, Priyanka, Spijker, Sabine, Mansvelder, Huibert D., Choquet, Daniel, Smit, August B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778035/
https://ncbi.nlm.nih.gov/pubmed/26931375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10682
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