Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by (13)C NMR Spectroscopy of Perfused Tumor Cells

A network model for the determination of tumor metabolic fluxes from (13)C NMR kinetic isotopomer data has been developed and validated with perfused human DB-1 melanoma cells carrying the BRAF V600E mutation, which promotes oxidative metabolism. The model generated in the bonded cumomer formalism d...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Shestov, Alexander A., Mancuso, Anthony, Lee, Seung-Cheol, Guo, Lili, Nelson, David S., Roman, Jeffrey C., Henry, Pierre-Gilles, Leeper, Dennis B., Blair, Ian A., Glickson, Jerry D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2016
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777850/
https://ncbi.nlm.nih.gov/pubmed/26703469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.701862
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