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Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism

RPE65 is the isomerase catalyzing conversion of all-trans-retinyl ester (atRE) into 11-cis-retinol in the retinal visual cycle. Crystal structures of RPE65 and site-directed mutagenesis reveal aspects of its catalytic mechanism, especially retinyl moiety isomerization, but other aspects remain to be...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Eroglu, Abdulkerim, Gentleman, Susan, Poliakov, Eugenia, Redmond, T. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777834/
https://ncbi.nlm.nih.gov/pubmed/26719343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685651
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