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Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism
RPE65 is the isomerase catalyzing conversion of all-trans-retinyl ester (atRE) into 11-cis-retinol in the retinal visual cycle. Crystal structures of RPE65 and site-directed mutagenesis reveal aspects of its catalytic mechanism, especially retinyl moiety isomerization, but other aspects remain to be...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4777834/ https://ncbi.nlm.nih.gov/pubmed/26719343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.685651 |
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