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Aromatic lipophilic spin traps effectively inhibit RPE65 isomerohydrolase activity()
We previously showed that RPE65 does not specifically produce 11-cis retinol only but also 13-cis retinol, supporting a carbocation or radical cation mechanism of isomerization. The intrinsic properties of conjugated polyene chains result in facile formation of radical cations in oxidative condition...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169428/ https://ncbi.nlm.nih.gov/pubmed/21736383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200532m |
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