Aromatic Residues in the Substrate Cleft of RPE65 Protein Govern Retinol Isomerization and Modulate Its Progression

Previously, we showed that mutating RPE65 residue Phe-103 preferentially produces 13-cis-retinol instead of 11-cis-retinol, supporting a carbocation/radical cation mechanism of retinol isomerization. We asked whether this modulation of specificity can occur with residues other than Phe-103 and what...

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Bibliographic Details
Main Authors: Chander, Preethi, Gentleman, Susan, Poliakov, Eugenia, Redmond, T. Michael
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436303/
https://ncbi.nlm.nih.gov/pubmed/22745121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.364596
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