Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling

Human colon cancers commonly harbor loss of function mutations in APC, a repressor of the canonical WNT pathway, thus leading to hyperactive WNT-TCF signaling. Re-establishment of Apc function in mice, engineered to conditionally repress Apc through RNAi, resolve the intestinal tumors formed due to...

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Udgivet i:PLoS One
Main Authors: Seth, Chandan, Ruiz i Altaba, Ariel
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777488/
https://ncbi.nlm.nih.gov/pubmed/26939070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150697
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