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Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts
OBJECTIVE: Internal tandem duplication (ITD) mutations of the FLT3 receptor are associated with a high incidence of relapse in acute myeloid leukemia (AML). Expression of the CXCR4 receptor in FLT3-ITD–positive AML is correlated with poor outcome, and inhibition of CXCR4 was shown to sensitize AML b...
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| Опубликовано в: : | Exp Hematol |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4777334/ https://ncbi.nlm.nih.gov/pubmed/20035824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2009.12.003 |
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